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KMID : 0613320010070010001
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Journal of the Korean Bone and Joint Tumor Soceity
2001 Volume.7 No. 1 p.1 ~ p.12
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Cellular Toxicity of Adriamycin Eluted from Adriamycin-impregnated Bone Cement
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Jang Dong-Wook
Kim Byung-Suck
Choi Sun-Sil
Choi Seung-Jun
Awe Soo-Ik
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Abstract
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Purpose: To elucidate possibility of local chemotherapy from adraimycin-impregnated bone cement.
Materials and Methods: Authors used 4 kinds of bone cements, Palcos R, LVC, CMW 3, Simplex P for this experimental model, included 2.5㎎, 5㎎, 25 ㎎of adriamycin, respectively. We compared the differences of eluted-adriamycin concentrations between the cylindrical shape and the flat shape of bone cements, between ddH2O, 0.45% saline, 0.9% saline, and 3% saline as one of environmental conditions. Osteosarcoma cell line, Saos-2 were cultured under 37 。C, 5% CO2 in the humidified incubator with three different concentrations of adriamycin-impregnated bone cements and cellular toxicity of adriamycin eluted from bone cement was analysed according to MTT assay.
Results: Authors noticed the flat shape of bone cement eluted more concentrations of adri-amycin than the cyclindrical shape, bone cement immersed in 3% saline, more than 0.9% or 0.45% saline. Concentrations of adriamycin eluted from CMW 3 or Simplex R were more than Palacos R or LVC. Saos-2 were cultured with 2.5 ㎎, 5 ㎎, 25 ㎎ of adriamycin-impregnated bone cement, respectively, and their cellular toxicity were 95%, 98%, 99%, each.
Conclusion: Adriamycin-impregnated bone cement can be one of anticancer-drug delivery sytems as possible local chemotherapy.
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KEYWORD
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Adriamycin-impregnated bone cement, Local chemotherapy
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